Amanda Seyfried Opens Up About Her Surprise Return as Elizabeth Holmes in ‘You Can See Everything’

Nathan Fielder's latest project has kept audiences guessing since it hit theaters last month. Now, one of its biggest stars is opening up about the role she couldn't discuss until recently.

Amanda Seyfried couldn't wait to finally talk about her surprise return as disgraced Theranos founder Elizabeth Holmes in Nathan Fielder's new documentary, "You Can See Everything."

The actress opened up about her involvement while attending the New York City premiere of her new animated film "Steps" on Saturday, November 8. Asked how she felt now that her secret cameo was out in the open, she replied, "Relieved."

"Excited," she added. "It's important for me as an actor, an artist, I mean, a mom, of course, but as a person in the world who loves to work, to find things that I haven't done before and to do things that scare me in a specific way."

"And when you follow through with something that scares you and it comes out the other end that it's something that's having an impact, mostly positive impact, it always feels good because you take a risk," she continued.

Co-directed by Fielder and Lance Oppenheim, "You Can See Everything" picks up 34 days before Holmes, 42, begins her prison sentence for fraud.

Cameras follow the former Theranos CEO through her final weeks of freedom with her partner, William "Billy" Evans, and their family, capturing an unusually personal side of her before she's incarcerated.

The film doesn't stay straightforward for long. As Fielder works to understand the woman at its center, the project veers in surprising directions, mixing traditional documentary footage with staged reenactments until the two become hard to tell apart.

Few twists land quite like Seyfried's appearance. The actress was left out of every trailer and promotional campaign ahead of the film's October 16 theatrical release, keeping her role under wraps until audiences saw it for themselves.

Once Holmes had reported to prison, Fielder, 43, and his team brought the actress in to watch much of the material they had filmed. Among the footage was a striking moment showing Holmes watching Seyfried play her in Hulu's limited series "The Dropout" for the first time.

Seyfried then steps in front of the documentary's cameras herself, reprising her role as Holmes to recreate conversations and encounters that Fielder never managed to film.

Through her performance, the filmmaker's recollections of those exchanges play out on screen, with the actress once again inhabiting a character she first portrayed several years ago.

Her turn in "The Dropout" earned her both an Emmy and a Golden Globe, a testament to how completely she disappeared into the role of the former Theranos founder.

The Hulu series traces Holmes' rise at Theranos, the blood-testing startup she founded on the promise of running numerous medical tests from just a few drops of blood. Those claims eventually fell apart, and Holmes was later convicted of fraud and conspiracy.

During a conversation at the 2026 Toronto International Film Festival, Seyfried reflected on her desire to take on characters that offer fresh challenges and perspectives.

"I mean, I've always been looking for complexity and to get as much perspective as I possibly can as an artist," she shared. "I feel like right now people are seeking me out to play these roles, which is just a real privilege."