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Christina Applegate | Source: Getty Images
Christina Applegate | Source: Getty Images

Christina Applegate Hospitalized for Kidney Infection

Olena Mosiichuk
Aug 06, 2025 - 10:31 A.M.

The "Married… with Children" actress, who has been battling multiple sclerosis (MS) since 2021, recorded an episode of her podcast from the hospital, talking about her experience.

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Christina Applegate shared that she has been hospitalized due to a kidney infection that spread to both kidneys. The actress revealed the news during an episode of her "MeSsy" podcast with her co-host Jamie-Lynn Sigler.

Christina Applegate attends the 29th Annual Screen Actors Guild Awards at Fairmont Century Plaza on February 26, 2023, in Los Angeles, California. | Source: Getty Images

Christina Applegate attends the 29th Annual Screen Actors Guild Awards at Fairmont Century Plaza on February 26, 2023, in Los Angeles, California. | Source: Getty Images

Titled "Live from the Hospital," the segment was taped in a Los Angeles hospital and was released on Tuesday, August 5. Applegate shared that she began feeling unwell while visiting family in Europe.

"I was not feeling good the whole time I was there, but not like the kind of bad where I had missed days. It would just be like up and down. Like, I'd be okay for a couple hours and then I'd be having to go lay down because my stomach was really bad," she explained.

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Christina Applegate speaks speaks onstage during the 75th Primetime Emmy Awards at Peacock Theater on January 15, 2024, in Los Angeles, California. | Source: Getty Images

Christina Applegate speaks speaks onstage during the 75th Primetime Emmy Awards at Peacock Theater on January 15, 2024, in Los Angeles, California. | Source: Getty Images

Upon returning to the States, Applegate said she was "really afraid" to go back home, only to end up needing to run to the emergency room in the early hours of the morning. So, she decided to head straight to the hospital. The film star advocated for her treatment and asked to be admitted.

"I want to know why this is happening, and I want it to stop so that I don't have to keep coming here," she said of her condition. "I wanna be admitted. I'm staying here because I want answers. I want every test that you can possibly think of or ones that you haven't even thought of, and I want them done."

Christina Applegate poses with her star during her Hollywood Walk of Fame Ceremony at Hollywood Walk Of Fame on November 14, 2022, in Los Angeles, California. | Source: Getty Images

Christina Applegate poses with her star during her Hollywood Walk of Fame Ceremony at Hollywood Walk Of Fame on November 14, 2022, in Los Angeles, California. | Source: Getty Images

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The following day, Applegate said she woke up with excruciating pain on her right side that was radiating from her back to the front. "They ordered me an emergency CT at 2 o'clock in the morning," she shared.

She continued, "I went in and got a CT, and I had kidney infections. And so I'm here because of this kidney infection and I have to have intravenous antibiotics right now." Applegate has since been discharged from the hospital.

"I'm home and have been treated for the kidney infection," she said in a statement to PEOPLE via her representative, on Tuesday afternoon. "As far as my ongoing stomach thing, it's a work in progress. I was there 7 days."

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